Focus on human microbiome to fight liver cirrhosis
22 European institutions join forces in MICROB-PREDICT to improve the prevention and treatment of chronic liver disease (cirrhosis). We aim to identify microbiome-based biomarkers and mechanisms that predict in advance when the body can no longer compensate for the dysfunctional liver (decompensated cirrhosis), when such decompensated cirrhosis will progress to acute-on-chronic liver failure (ACLF), and a patient’s individual treatment response. Based on such biomarkers, we strive to develop novel diagnostic tools for earlier and better patient stratification and to establish personalised and effective treatment strategies.
ALB-TRIAL reaches 25% enrolment goal
We are pleased to announce that the MICROB-PREDICT initiative ALB-TRIAL has reached an important milestone, with 25% of the targeted 240 patients now enrolled. Patients have been enrolled from nine active centres around Europe with additional sites expected to initiate patient inclusion shortly.
ALB-TRIAL is a European, double-blinded, placebo-controlled clinical trial. It aims to validate a biomarker developed within the MICROB-PREDICT project to assess how the body responds to albumin treatment in patients with cirrhosis. The trial seeks to identify patients who could benefit from long-term albumin therapy, potentially improving their symptoms, reducing complications, and lowering the risk of death.
This milestone reflects the dedicated efforts of all sites across Europe, and we would like to thank everyone for their work. We are excited to advance further toward the completion of ALB-TRIAL.
More newsCelebrating Milestone for MICROB-PREDICT Project: Terlipressin Study Hits 1,000 Downloads!
We are excited to announce that the groundbreaking research from the MICROB-PREDICT project, "Terlipressin therapy is associated with increased risk of colonisation with multidrug‐resistant bacteria in patients with decompensated cirrhosis" has surpassed 1,000 full-text views and downloads on Wiley Online Library. This milestone underscores the significant impact of this important study, which highlights the potential risks of terlipressin treatment in patients with advanced liver disease.
We would like to thank the research community and all those who have engaged with this work. The attention it’s received reflects the growing interest in understanding the complex interactions between antimicrobial resistance and cirrhosis care.
More newsMICROB-PREDICT project video
Focus on human microbiome to fight liver cirrhosis: 22 European institutions joined forces in January 2019 to improve the prevention and treatment of chronic liver disease (cirrhosis) within the MICROB-PREDICT project. We aim to identify microbiome-based biomarkers and mechanisms that predict in advance when the body can no longer compensate for the dysfunctional liver (decompensated cirrhosis) and decompensated cirrhosis progresses to acute-on-chronic liver failure (ACLF), and individual treatment responses of patients. Coordinator Jonel Trebicka gives a brief overview of the project in this video.
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