Focus on human microbiome to fight liver cirrhosis

22 European institutions join forces in MICROB-PREDICT to improve the prevention and treatment of chronic liver disease (cirrhosis). We aim to identify microbiome-based biomarkers and mechanisms that predict in advance when the body can no longer compensate for the dysfunctional liver (decompensated cirrhosis), when such decompensated cirrhosis will progress to acute-on-chronic liver failure (ACLF), and a patient’s individual treatment response. Based on such biomarkers, we strive to develop novel diagnostic tools for earlier and better patient stratification and to establish personalised and effective treatment strategies.

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MICROB-PREDICT Results Videos: Sharing our innovation with scientists and liver patients

As the project approaches the finish line (September 2026), MICROB-PREDICT has launched a comprehensive 17-part results video series to showcase its scientific achievements and maximise the project's long-term impact. The collection includes eight Expert Presentations highlighting key discoveries on biomarkers, microbiome research, multi-omics, gut barrier dysfunction, metabolomics and novel therapeutic targets for cirrhosis and ACLF, alongside nine Easy Results Videos that translate these advances for patients and the general public - featuring ELPA president Marko Korenjak as interviewer. Together, these video series help bridge the gap between research, clinical practice, and patient understanding, ensuring that MICROB-PREDICT's discoveries continue to inform both future liver disease research and improved care for patients.

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MICROB-PREDICT at EASL 2026: Driving advances in precision hepatology

In the final project year, MICROB-PREDICT consortium members showcased their work with an exceptionally strong presence at EASL Congress in Barcelona from 27-30 May 2026, contributing more than 50 activities (oral presentations, posters, educational sessions and symposia on biomarkers, microbiome-host interactions, cirrhosis, portal hypertension, liver transplantation, precision medicine, as well as promotional visuals and info materials about MICROB-PREDICT itself). A key highlight was the MICROB-PREDICT Consensus Conference on 27 May, followed by a dedicated Networking Session on 30 May - presenting the consensus outcomes on microbiome-based mechanisms and biomarkers for improved patient stratification and care in cirrhosis and ACLF. Congratulations to the entire team for the fantastic representation!

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MICROB-PREDICT project video

Focus on human microbiome to fight liver cirrhosis: 22 European institutions joined forces in January 2019 to improve the prevention and treatment of chronic liver disease (cirrhosis) within the MICROB-PREDICT project. We aim to identify microbiome-based biomarkers and mechanisms that predict in advance when the body can no longer compensate for the dysfunctional liver (decompensated cirrhosis) and decompensated cirrhosis progresses to acute-on-chronic liver failure (ACLF), and individual treatment responses of patients. Coordinator Jonel Trebicka gives a brief overview of the project in this video.

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