Publications
View topic-related background literature as well as publications of the MICROB-PREDICT consortium itself. To receive our newsletter, please subscribe here!
MICROB-PREDICT Publications
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Castelli F.A., Rosati G., Moguet C., Fuentes C. et al. (2022)
Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests
Analytical and Bioanalytical Chemistry, Volume 414, Issue 2, pp. 759-789 -
Chandana B. Herath, Peter W. Angus and Jonel Trebicka (2022)
Editorial: Portal Hypertension in Cirrhosis: From Pathogenesis to Novel Treatments
Frontiers in Physiology, Volume 13 (864083) -
Johannes Chang, Pauline Höfer, Nina Böhling, Philipp Lingohr, Jonel Trebicka et al. (2022)
Preoperative TIPS prevents the development of postoperative acute-on-chronic liver failure in patients with high CLIF-C AD score
JHEP Reports, Volume 4, Issue 3 (100442) -
Menghao Li, Kai Li, Shihao Tang, Yong Lv, Jonel Trebicka et al. (2022)
Restoration of the gut microbiota is associated with a decreased risk of hepatic encephalopathy after TIPS
JHEP Reports, Volume 4, Issue 5 (100448) -
Verónica Prado, María Hernández-Tejero, Fátima Aziz, Jonel Trebicka et al. (2022)
Rectal colonization by resistant bacteria increases the risk of infection by the colonizing strain in critically ill patients with cirrhosis
Journal of Hepatology, Volume 76, Issue 5, pp. 1079-1089 -
Xiaojie Yu, Natalia Elfimova, Marion Müller et al. (2022)
Autophagy-Related Activation of Hepatic Stellate Cells Reduces Cellular miR-29a by Promoting Its Vesicular Secretion
CMGH, Volume 13 Issue 6, pp. 1701-1716 -
Xinxing Tantai, Yi Liu, Yee Hui Yeo, Michael Praktiknjo, Jonel Trebicka et al. (2022)
Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis
Journal of Hepatology, Volume 76, Issue 3, pp. 588-599 -
Abraldes JG, Albillos A, Baiges A, Bajaj J et al. (2021)
Baveno VII – Renewing consensus in portal hypertension
Journal of Hepatology, Volume 76, Issue 4, pp. 959-974 -
Alexander Queck, Frank E Uschner, Philip G Ferstl, Martin Schulz, Jonel Trebicka et al. (2021)
Role of circulating angiogenin levels in portal hypertension and TIPS
PLoS One, Volume 16, Issue 8, e0256473 -
Castelli FA, Rosati G, Moguet C et al. (2021)
Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests
Anal Bioanal Chem: 1-31. Online ahead of print. -
Chang Johannes, Meinke Jonathan, Wehner Sven, Trebicka Jonel et al. (2021)
Extrahepatic Surgery in Cirrhosis Significantly Increases Portal Pressure in Preclinical Animal Models
Frontiers in Physiology, Volume 12, pp. 720-898 -
Clària, J., Curto, A., Moreau, R., Colsch, B., López-Vicario, C., Trebicka, J. et al. (2021)
Untargeted lipidomics uncovers lipid signatures that distinguish severe from moderate forms of acutely decompensated cirrhosis
Journal of Hepatology, Volume 75, Issue 5, pp. 1116-1127 -
Cornelius Engelmann, Adam Herber, Annegret Franke, Tony Bruns et al. (2021)
Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: A multicenter randomized trial (GRAFT study)
Journal of Hepatology, Volume 75, Issue 6, pp. 1346-1354 -
Delia Blaya, Elisa Pose, Mar Coll, Joan Caballería, Jonel Trebicka, et al. (2021)
Profiling circulating microRNAs in patients with cirrhosis and acute-on-chronic liver failure
JHEP Reports, Volume3, Issue 2 (100233) -
Diehl Valentina, Huber Lisa Sophie, Trebicka Jonel, Wygrecka Malgorzata, Iozzo Renato V., Schaefer Liliana (2021)
The Role of Decorin and Biglycan Signaling in Tumorigenesis
Frontiers in Oncology, Volume 11 -
Dr. med. Philip Ferstl, Dr. med. Jonel Trebicka (2021)
Acute Decompensation and Acute-on-Chronic Liver Failure
Clinics in Liver Disease, Volume 25, Issue 2, pp. 419-430 -
Fuentes-Chust C., Parolo C., Rosati G., Rivas L., Perez-Toralla K., Simon S., de Lecuona I., Junot C., Trebicka J., Merkoçi A. (2021)
The Microbiome Meets Nanotechnology: Opportunities and Challenges in Developing New Diagnostic Devices
Advanced Materials, Volume 33, Issue 18 (2006104) -
Geyer PE, Mann SP, Treit PV, Mann M. Plasma (2021)
Plasma Proteomes Can Be Reidentifiable and Potentially Contain Personally Sensitive and Incidental Findings
Molecula & Cellular Proteomics 20 (10035) -
Innes H, Nischalke HD, Guha IN, Weiss KH, Irving W, Gotthardt D, Barnes E, Fischer J, Ansari MA, Trebicka J et al. (2021)
The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis
Hepatology Communications, Volume 6, Issue 5, pp. 1213-1226 -
Jenny Bischoff, Wenyi Gu, Jonel Trebicka et al. (2021)
Stratifying the risk of NAFLD in patients with HIV under combination antiretroviral therapy (cART)
EClinicalMedicine, Volume 40 (101116) -
Johannes Chang, Avend Bamarni, Nina Böhling, Jonel Trebicka et al. (2021)
Elective Surgery but not Transjugular Intrahepatic Portosystemic Shunt Precipitates Acute-On-Chronic Liver Failure
Hepatology Communications, Volume 5, Issue 7, pp. 1265-1277 -
Martin Schulz, Jonel Trebicka (2021)
Acute-on-chronic liver failure: a global disease
Gut BMJ Volume 71, Issue 1, pp. 5-6 -
Michael Praktiknjo, Jasmin Abu-Omar, Jonel Trebicka et al (2021)
Controlled underdilation using novel VIATORR® controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation
JHEP Volume 3, Issue 3, 100264 -
Rosati G., Idili A., Parolo C., Fuentes-Chust C., et al. (2021)
Nanodiagnostics to Face SARS-CoV‑2 and Future Pandemics: From an Idea to the Market and Beyond
ACS Nano, Volume 15, Issue 11, pp. 17137-17149 -
Rosati G., Urban M., Zhao L., et al. (2021)
A plug, print & play inkjet printing and impedance-based biosensing technology operating through a smartphone for clinical diagnostics
Biosensors and Bioelectronics Volume 196, p. 1-10 -
Sebastian Porsdam Mann, Peter V.Treit, Philipp E.Geyer, Gilbert S.Omenn, MatthiasMann (2021)
Ethical Principles, Constraints, and Opportunities in Clinical Proteomics
MCP, Volume 20, 100046 -
Sturm, L., Praktiknjo, M., Bettinger, D., Trebicka, J., et al. (2021)
Prognostic Value of the CLIF-C AD Score in Patients With Implantation of Transjugular Intrahepatic Portosystemic Shunt
Hepatology Communications, Volume 5, pp. 650-660 -
Suyanpeng Zhang, Sze-Chuan Suen, Cynthia L.Gong, Jessica Pham, Jonel Trebicka, et al. (2021)
Early transplantation maximizes survival in severe acute-on-chronic liver failure: Results of a Markov decision process model
JHEP Reports, Volume 3 Issue 6, pp. 100 -
Tao Lin, Shanshan Wang, Stefan Munker, Kyounghwa Jung, Ricardo U. Macías-Rodríguez, Jonel Trebicka et al. (2021)
Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure
Hepatology, Volume 75, Issue 2, pp. 322-337 -
Tilman Sauerbruch, Martin Hennenberg, Jonel Trebicka and Ulrich Beuers (2021)
Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction
Frontiers in Physiology (29.07.2021), pp. 718-783 -
Torres Sandra, Brol Maximilian J, Magdaleno Fernando, Schierwagen Robert, Uschner Frank E., Klein Sabine, Trebicka Jonel et al. (2021)
The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis
Frontiers in Molecular Biosciences, Volume 8, (715765) -
Tranah TH, Edwards LA, Schnabl B et al. (2021)
Targeting the gut-liver-immune axis to treat cirrhosis
Gut. 70: 982-994. -
Trebicka J, Bork P, Krag A, Arumugam M. (2021)
Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure
Nat Rev Gastroenterol Hepatol. 18: pp. 167–180. -
Trebicka J, Gu W, de Ledinghen V, Aubé C, Krag A, Praktiknjo et al. (2021)
Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease
GUT, Volume 71, Issue 3, pp. 402-414 -
Trebicka J, MacNaughtan J, Schnabl B, Shawcross DL and Bajaj JS. (2021)
The microbiota in cirrhosis and its role in hepatic decompensation
Journal of Hepatology, Vollume 75, Suppl. 1, pp. 67-81 -
Trebicka J., Bork P., Krag A., Arumugam M. (2021)
Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure.
Nature Reviews Gastroenterology & Hepatology, Volume 18, Issue 3, pp. 167-180 -
Wenyi Gu, Hannah Hortlik, Hans-Peter Erasmus, Louisa Schaaf, Yasmin Zeleke, Jonel Trebicka et al. (2021)
Trends and the course of liver cirrhosis and its complications in Germany: Nationwide population-based study (2005 to 2018)
The Lancet Regional Health - Europe, Volume 12 (100240) -
Yasuko Iwakiri, Jonel Trebicka (2021)
Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy
JHEP Reports, Volume 3, Issue 4 (100316) -
Bader JM, Geyer PE, Müller JB et al. (2020)
Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer’s disease
Mol Syst Biol. 16: e9356 -
Benz F, Bogen A, Praktiknjo M et al. (2020)
Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis
PLoS One. 15(4): e0231701. -
Cremonese C, Schierwagen R, Uschner FE et al. (2020)
Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats
Int J Mol Sci. 21(9): 3308. -
Cullaro G, Sharma R, Trebicka J et al. (2020)
Precipitants of Acute-on-Chronic Liver Failure: An Opportunity for Preventative Measures to Improve Outcomes
Liver Transpl. 26(2): 283-293. -
García-Pagán JC, Bosch J, Trebicka J et al. (2020)
Letter: improve survival! Place early pre-emptive TIPSS in high-risk variceal bleeders
Aliment Pharmacol Ther. 52(5): 927-928. -
Itziar de Lecuona Ramírez (2020)
Pautes per avaluar projectes de recerca i innovació en salut que utilitzin tecnologies emergents i dades personals
Published by: Edicions de la Universitat de Barcelona -
Karl P. Rheinwalt; Uta Drebber et al. (2020)
Baseline Presence of NAFLD Predicts Weight Loss after Gastric Bypass Surgery for Morbid Obesity
Journal of Clinical Medicine Volume 9, Issue 11, pp. 3430 -
López-Vicario C, Checa A, Urdangarin A et al. (2020)
Targeted lipidomics reveals extensive changes in circulating lipid mediators in patients with acutely decompensated cirrhosis
J Hepatol. 73(4): 817-828. -
Monteiro S, Grandt J, Uschner FE et al. (2020)
Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation
Gut. 70: 379-387. -
Müller JB, Geyer PE, Colaço AR et al. (2020)
The proteome landscape of the kingdoms of life
Nature. 582: 592–596. -
Praktiknjo M, Simón-Talero M, Römer J et al. (2020)
Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis
J Hepatol. 72(6): 1140-1150. -
Queck A, Bode H, Uschner FE et al. (2020)
Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis
Front Immunol. 11: 354. -
Robert Schierwagen, Peter Dietrich, Tilman Sauerbruch, Jonel Trebicka et al. (2020)
β-Arrestin2 is increased in liver fibrosis in humans and rodents
PNAS, Volume 117, No. 44, pp. 27082-27084 -
Schierwagen R, Uschner FE, Ortiz C et al. (2020)
The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease
Front Immunol. 11: 1352. -
Torres S, Abdullah Z, Brol MJ et al. (2020)
Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview
Int J Mol Sci. 21(6): 2027. -
Trebicka J, Sundaram V, Moreau R et al. (2020)
Liver Transplantation for Acute-on-Chronic Liver Failure: Science or Fiction?
Liver Transpl. 26(7): 906-915. -
Tyc O, Jansen C, Schierwagen R et al. (2020)
Variation in Bile Microbiome by the Etiology of Cholestatic Liver Disease
Liver Transpl. 26: 1652-1657. -
Van Rossum T, Ferretti P, Maistrenko OM et al. (2020)
Diversity within species: interpreting strains in microbiomes
Nat Rev Microbiol. 18: 491–506. -
Zeng-Brouwers J, Pandey S, Trebicka J et al. (2020)
Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases
J Histochem Cytochem. 68(12): 887-906. -
Coenraad M, Papp M, Trebicka J et al. (2019)
MICROB-PREDICT – 15 millió eurós költségvetéssel induló mikrobiom kutatási vizsgálat az Európai Unióban
Central European Journal of Gastroenterology and Hepatology. -5 : 2 (2019), p. 40-42. -CEU-JGH. - 2415-9107 -
Casey S, Schierwagen R, Mak KY et al. (2019)
Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation
J Clin Med. 8(4): 419. -
Klein LM, Chang J, Gu W et al. (2019)
The Development and Outcome of Acute-on-Chronic Liver Failure After Surgical Interventions
Liver Transpl. 26(2): 227-237. -
Korenjak M, Všetičkova V, Credi B. (2019)
ELPA and EU medical research project brochure
Booklet. Relevant pages: 20-23. -
Praktiknjo M, Clees C, Pigliacelli A et al. (2019)
Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt
Clin Transl Gastroenterol. 10(4): e00025. -
Queck A, Carnevale R, Uschner FE et al. (2019)
Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS
Gut. 69: 1535–1536 -
Queck A, Thomas D, Jansen C et al. (2019)
Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis
PLoS One. 14(10): e0222840. -
Schierwagen R, Alvarez-Silva C, Servant F et al. (2019)
Trust is good, control is better: technical considerations in blood microbiome analysis
Gut. 69(7): 1362-1363. -
Torner M, Mangal A, Scharnagl H et al. (2019)
Sex specificity of kidney markers to assess prognosis in cirrhotic patients with TIPS
Liver Int. 40(1): 186-193.
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Background Literature
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Trebicka J, Fernandez J, Papp M et al. (2020)
The PREDICT study uncovers three clinical courses in acutely decompensated cirrhosis with distinct pathophysiology.
Journal of Hepatology, DOI: 10.1016/j.jhep.2020.06.013. -
Trebicka J, Fernandez J, Papp M et al. (2020)
PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
Journal of Hepatology. doi: 10.1016/j.jhep.2020.11.019. -
Alvarez-Silva C, Schierwagen R, Pohlmann A et al. (2019)
Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis.
Front Immunol. 10: Article number 69. -
Clària J, Moreau R, Fenaille F et al. (2019)
Orchestration of Tryptophan-Kynurenine Pathway, Acute Decompensation, and Acute-on-Chronic Liver Failure in Cirrhosis.
Hepatology. 69 (4):1686-1701. -
Fernández J, Prado V, Trebicka J et al. (2019)
Multidrug-resistant bacterial infections in patients with decompensated cirrhosis and with acute-on-chronic liver failure in Europe.
J. Hepatol. 70 (3):398-411. -
Letunic I, Bork P (2019)
Interactive Tree Of Life (iTOL) v4: recent updates and new developments.
Nucleic Acids Res. 47 (1):256-259. -
Niu L, Geyer PE, Wewer Albrechtsen NJ et al. (2019)
Plasma proteome profiling discrovers novel proteins associated with non-alcoholic fatty liver disease.
Mol Syst Biol. 15: Article number 8793. -
Quesada-González D, Sena-Torralba A, Wicaksono WP et al. (2019)
Iridium oxide (IV) nanoparticle-based lateral flow immunoassay.
Biosens Bioelectron. 132: 132-135. -
Romanov N, Kuhn M, Aebersold R et al. (2019)
Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals.
Cell. 177 (5):1308-1318. -
Schmidt TS, Hayward MR, Coelho LP (2019)
Extensive transmission of microbes along the gastrointestinal tract.
Elife. 8: Article number 42693. -
Solà E, Solé C, Ginès P (2019)
New Strategies for the Management of Decompensated Cirrosis: Long-Term Albumin Administration for Everyone?
Hepatology. 69 (5):2289-2291. -
Trebicka J, Amoros A, Pitarch C et al. (2019)
Addressing Profiles of Systemic Inflammation Across the Different Clinical Phenotypes of Acutely Decompensated Cirrhosis.
Front Immunol. 10: Article number 476. -
Schierwagen R, Alvarez-Silva C, Madsen MSA et al. (2018)
Circulating microbiome in blood of different circulatory compartments.
Gut. In print -
Schmidt TSB, Raes J, Bork P (2018)
The human gut microbiome: From association to modulation.
Cell. 172 (6):1198-1215. -
Trebicka J, Reiberger T, Laleman W (2018)
Gut-liver axis links portal hypertension to acute-on-chronic liver failure.
Visc Med. 31 (4):270-275. -
Hackstein CP, Assmus LM, Welz M et al. (2017)
Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis.
Gut. 66 (3): 507-518. -
Arroyo V, Moreau R, Patrick S et al. (2016)
Acute-on-chronic liver failure in cirrhosis
Nature Reviews Disease Primers. 2: Article number 16041. -
Spinella R, Sawhney R and Jalan R (2016)
Albumin in chronic liver disease: structure, functions and therapeutic implications.
Hepatol Int. 10 (1): 124-32. -
Tilg H, Cani PD, Mayer EA (2016)
Gut microbiome and liver diseases.
Gut. 65 (12):2035-2044. -
Qin N, Yang F, Li A et al. (2014)
Alterations of the human gut microbiome in liver cirrhosis.
Nature. 513 (7516):59-64. -
Moreau R, Jalan R, Gines P et al. (2013)
Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis.
Gastroenterology. 144 (7):1426-1437.